分子量：Calculated MW: 77kDa/83kDa/86kDa/87kDa
Observed MW: 140kDa

细胞定位：Cell membrane, Early endosome membrane, Late endosome membrane, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000
IHC 1:50 - 1:200

总结：This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.