Anti-ZAP70 Monoclonal Antibody

宿主	Mouse
英文名称	Anti-ZAP70 Monoclonal Antibody
别名	ADMIO2;IMD48;SRK;STCD;STD;TZK;ZAP-70;SRK;STCD;STD;TZK;ZAP-70
应用	WB IP
稀释比例	WB 1:1000.
交叉反应	Human
蛋白分子量	70kDa
Gene ID	7535
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG2b
免疫原	Purified recombinant human ZAP70 protein fragments expressed in E.coli.
性状	液体
Subcellular Locations	Cell membrane Cytoplasm Peripheral membrane protein
Swiss Prot	P43403
克隆号	4B2-C1-H3
克隆类型	Monoclonal Antibody
背景资料	This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]