分子量：Calculated MW: 154kDa
Observed MW: 95kDa

细胞定位：Cell membrane, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:2000

总结：This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.