分子量：Calculated MW: 76kDa/87kDa
Observed MW: 110kDa

细胞定位：Cell membrane, Single-pass type I membrane protein

稀释方法：WB 1:500 - 1:1000
IF 1:50 - 1:200

总结：This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.