ULK3 Rabbit pAb (APR27522N)-抗体-抗体-生物在线
安诺伦(北京)生物科技有限公司
ULK3 Rabbit pAb (APR27522N)

ULK3 Rabbit pAb (APR27522N)

商家询价

产品名称: ULK3 Rabbit pAb (APR27522N)

英文名称: ULK3 Rabbit pAb (APR27522N)

产品编号: APR27522N

产品价格: null

产品产地: 美国

品牌商标: Leading Biology

更新时间: null

使用范围:

安诺伦(北京)生物科技有限公司
  • 联系人 :
  • 地址 : 北京大兴经济技术开发区天骥智谷35A
  • 邮编 :
  • 所在区域 : 北京
  • 电话 : 189****2642 点击查看
  • 传真 : 点击查看
  • 邮箱 : 3359689365@qq.com

分子量:Calculated MW: 24kDa/53kDa/54kDa
Observed MW: 60kDa

细胞定位:Cytoplasm

稀释方法:WB 1:500 - 1:2000

总结:Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3. Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.